researchers Anti-cancer and corona drug discovered The results obtained from the tests of this drug are very promising. Using the new drug compounds they have discovered, researchers can discover Anti-cancer and corona drug to announce
In addition to discovering anti-cancer and corona drugs, scientists are also looking for ways to treat severe infections. The results of this study were published in the journal Neoplasia and show that targeting GRP78 cells may help us fight these deadly cancers.
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An anti-cancer and anti-corona drug was discovered
A team of researchers from USC’s Keck School of Medicine has shown that the drug HA15 In the body of mice infected with SARS-CoV-2 virus, by blocking the production of chaperone protein, it has greatly reduced the viral load in the lungs.
The results of the study show that blocking the production of GRP78 or disrupting its activity using this new targeted drug prevents proliferation. covid virus prevents. The researchers found that the drug HA15, like another drug called YUM70, can disrupt the activity of GRP78 cells. YUM70 drug has an effective role in suppression Cancer cells He is a carrier of pancreatic, lung and colon cancer.
Despite the fact that in the current situation, vaccination can protect us against coronavirus To a large extent, scientists continue to research ways to treat severe infections.
The research team of Keck Medical School with the strategy of “Amy S. Lee, PhD, professor of biochemistry and molecular medicine, has now shown that a chaperone protein known as GRP78 plays an important role in the spread of SARS-CoV-2. The results of this study have been published in Nature Communications. Amy S. Lee says:
One of the main problems in fighting SARS-CoV-2 is that it is constantly mutating and adapting to infect and replicate more effectively in host cells.
Researchers to solve this problem to investigate the role GRP78 studied and found that while healthy cells need a fraction of GRP78 for normal function, stressed cells need more GRP78 to cope. In a 2021 study, researchers showed that when SARS-CoV-2 enters the scene, GRP78 disappears.
The team doubted whether GRP78 to reproduce covid virus Is it necessary inside human lung cells? When they examined human lung epithelial cells infected with SARS-CoV-2, they found that Viral infectioninfected cells produce higher levels of GRP78.
As a result, Lee and his research team decided to conduct experiments and finally proved that GRP78 is necessary for reproduction and production. Corona virus It is essential. Finally, the research team tested a drug called HA15 on infected lung cells. Ha15 was found to be effective against cancer cells and to bind GRP78.
The researchers then tested HA15 in genetically engineered mice infected with SARS-CoV-2 and found that the drug greatly reduced the viral load in the lungs. Li and his colleagues are still investigating these drugs.
The results of this study in the journal Neoplasia published and suggests that targeting GRP78 may help combat this Deadly cancersbe helpful
More research and clinical trials are still needed to prove the effectiveness of HA15 and YUM70 in humans.
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